HEMONC: Granulocytic sarcoma of the stomach: relapse after hematopoietic stem-cell transplantation for chronic myeloid leukemia

Granulocytic sarcoma of the stomach: relapse after hematopoietic stem-cell
transplantation for chronic myeloid leukemia
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<p><span style="font-size: small; font-family: verdana,geneva;">Antonio Vaz Macedo, Izabela F. Freitas, Fábio M. Oliveira, Clarissa C. Resende, Cláudia Maria C. Mendes, Ana Karine Vieira, Lúcia P. Castro, Eduardo M. Rego, Nelma Cristina D. Clementino, Henrique Bittencourt <br /></span></p> on 14/06/2010 09:44:00
 
Relapse of the underlying disease is the commonest cause of treatment failure
after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is
related to a poorer outcome.1-3 Most relapses occur within the first two years
of transplant.2 Chronic myeloid leukemia (CML) in first chronic phase is among
those with the lowest rates (10%-30%) of relapse.4 On rare occasions, an
isolated extramedullary presentation is seen.2,3 In a large retrospective
multicenter survey by Békassy et al, extramedullary relapse was reported in
only 6 of 2753 (0.22%) grafted patients among the CML/myelodysplastic subgroup.3
In this report, we describe a rare presenting feature of post-transplant relapse
of CML and discuss the main therapeutic alternatives in this setting.